Year: 2025 | Month: April-June | Volume: 10 | Issue: 2 | Pages: 10-20
DOI: https://doi.org/10.52403/gijhsr.20250202
Deciphering the Role of Vitamin D on Cardiac Physiology in Patient with Predialysis Diabetic and Non-Diabetic Chronic Kidney Diseases: An Observational Report
K Patar1, M Mukhopadhyay2, N Chakrabarti3, P Mukhopadhyay4, K Ganguly5, S Chatterjee6
1MD, Specialist Medical Officer, Department of Medicine, Deben Mahato Medical College, Purulia, West Bengal.
2MD, MRCP (Ireland), DM (Cardiology), FESC, CCDS (IBHRE USA), FSCAI, FACC, FAPSIC. Consultant Interventional Cardiologist, Department of Cardiology, Manipal Broadway Hospital, Saltlake, Kolkata.
3MD, FICP, Professor, Department of Medicine, IPGMER, Kolkata.
4MD, DM (Nephrology), Associate Professor, Department of Nephrology, NRSMCH, Kolkata.
5MD, DM (Cardiology), Ex-Professor and HOD, Department of Cardiology, NRSMCH, Kolkata.
6Senior Research Fellow, Department of Physiology, University of Calcutta.
Corresponding Author: Dr. Mainak Mukhopadhyay
ABSTRACT
Background: Chronic kidney disease (CKD) represents a significant global health issue, closely associated with cardiovascular complications. A notable prevalence of vitamin D deficiency exists among individuals with CKD, which may play a role in cardiovascular dysfunction; however, the precise nature of this relationship is not fully understood.
Objective: This study evaluates the effects of vitamin D deficiency on cardiovascular parameters in patients with CKD comparing those with diabetes to those without, in the eastern India.
Methods: A cross-sectional study was performed on individuals diagnosed with CKD to assess their levels of vitamin D, left ventricular mass index (LVMI), and ejection fraction (EF). Participants were divided based on their diabetic status and the stage of CKD. Statistical analyses were executed to identify potential associations between vitamin D deficiency and cardiovascular parameters.
Results: Diabetic patients with CKD exhibited a more severe deficiency of vitamin D than their non-diabetic counterparts. A significant link was established between low vitamin D concentrations and an increase in left ventricular mass index (LVMI), which may indicate a relationship with cardiac remodelling. However, no significant correlation was found between vitamin D levels and ejection fraction, implying that other variables may play a role in cardiac dysfunction associated with CKD.
Conclusion: Our findings indicate a pressing requirement for the early recognition and management of vitamin D deficiency in individuals with CKD, especially in diabetic patients, to alleviate cardiovascular risks. Further research is essential to investigate targeted therapeutic interventions.
Keywords: Chronic kidney disease, cardiovascular dysfunction, diabetic patients, vitamin D,